STRUGGLING MULTI-STRESS RESISTANT MYCOPLASMA PNEUMONIAE WITH BUILT-IN POTENCY, TOLERANCE BEHAVIOR TO ANTIBIOTICS, AND ULTRAVIOLET IRRADIATION *. B.

Biofilm ecosystems and the emergence of Mycoplasma pneumoniae strains with specific characteristics in certain regions and food sources. The presence of stress hardening and quorum sensing behavior within an enclosed ecosystem of the biofilm indicates a complex adaptation mechanism. In this case, the Mycoplasma pneumoniae strains encountered were epigenetically host-specific but had drifted adapted characteristics. These strains were found in dairy products from specific sectors in Baghdad, namely Abu-Ghraib, Al-Sadrya, and Al-Fudhaliyah, during seasonal episodes from January to June 2021. The presence of Mycoplasma pneumoniae in the food chain suggests contamination, which was deemed unacceptable. Within the biofilm ecosystem, a resident population consisting of Streptococci, Mycoplasma, and M. pneumoniae was identified, with the potential to form a potentiation wax barrier. The concerning aspect of these M. pneumoniae isolates was their multidrug resistance (MDR) phenotype, specifically to antibiotics with ESβL activity. Additionally, these strains displayed an Ultra Violet Tolerance (UVT) behavior, making them resistant to UV light exposure. Out of the eighteen isolates tested, sixteen (88.88%) were resistant to all selected antibiotics, with only moderate susceptibility to Norfloxacin, Aztreonam, and Azithromycin. The presence of UVT sublethal resuscitated clones indicated colony phase variation. Please note that this response is a summary of the information provided and may not capture all details accurately. It's important to consult the scientific literature or relevant experts for precise information on this topic.