EFFECT OF QUERCETIN EXTRACTED FROM ONION PEELS ON SOME PHYSIOLOGICAL PARAMETERS IN DIABETIC RATS

this experiment was conducted to find out the effect of the commercial and nano-extract of quercetin on the level of glucose and some physiological parameters, which included liver functions (alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase) and kidney functions (blood urea and creatinine), malondialdehyde and antioxidant enzymes (catalase). and superoxide dismutase) and lipid profiles (cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, and very low-density lipoproteins). The results showed a significant decrease in the weight of diabetic animals compared with the control group and groups treated with nano- and commercial quercetin extract after 30 days of dosing with Positive (infected without treatment) On the other hand, the results showed a significant increase in the level of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, blood urea and creatinine in the positive control group (infected without treatment) compared with groups treated with quercetin nano extract and commercial after 30 days In addition, the results showed that there was a significant increase in the level of malondialdehyde in the positive control group with the control group and the rest of the groups treated with the commercial and nano-extract quercetin, as well as a significant increase in the level of the catalase enzyme and a decrease in the level of the superoxide dismutase enzyme in the groups treated with the commercial and nano-quercetin extract compared with the positive control group . Finally, the results showed that there was a significant increase in the level of cholesterol, triglycerides, low-density lipoproteins and very low-density lipoproteins in the positive control group compared with the negative control group (non-diabetic) and the rest of the groups treated with nano- and commercial quercetin extract, while there was a significant increase in the level of lipoproteins High density in the aggregates treated with nano-quartzite and commercial compared with the positive control.