Research article

EVALUATION OF ANTI–INFLAMMATORY ACTIVITY OF PLANT EXTRACT OF CORDIA DICHOTOMA LEAVES ON CARRAGEENAN-INDUCED PAW EDEMA IN ALBINO WISTER RATS AND ITS PHYTOCHEMICAL ANALYSIS

Arpan Kumar Tripathi1*, Neha Sharma1, Jiten Mishra2, Digambar Bisoi2, Nityashree Mohapatra2, Md. Mohammad Muztaba3, Sandeep Gupta4, Bhumika Chandraker5, Darla Raju6, Ch. TarakaRamarao7

Online First: January 30, 2023


CORDIA DICHOTOMA (INDIAN CHERRY) is current research that examined the anti-inflammatory activity of a well-known indigenous medicinal plant that is used to treat pain, inflammation, diarrhea, tumors, and wounds, and as an anti-diabetic, anti-convulsant, anti-allergic, and anti-oxidant. The anti-inflammatory effect of an extract of leaves was tested in an experimental animal model of carrageenan-induced paw edema in the presence of control. In comparison to the reference standard, diclofenac 10 mg (1ml), the results showed that ethanolic extract greatly reduced edema. The findings of this study provide evidence for the use of this plant in the treatment of inflammatory diseases. the current study aimed at investigating the plant's anti-inflammatory activity using different experimental screening methods. This article summarizes the published literature on the anti-inflammatory activities of natural products. The effects of Cordia dichotoma leaves extracts on various stages of acute inflammation were investigated. The experiments were carried out in rats with different phlogistic agents-induced paw edema, namely carrageenan-induced paw edema. Various extracts (ethanol, petroleum ether, and aqueous) of Cordia dichotoma leaves were tested orally at doses of 500 mg/kg. The standard was diclofenac sodium at a dose of 10mg/kg. In these models, the extracts demonstrated significant activity (*p0.05 & ***p0.01) when compared to the control. Alkaloids, glycosides, saponins, tannins, and carbohydrates were discovered in the dry powdered seeds. According to the screening model, the ethanol extract and aqueous fraction of this plant have acute anti-inflammatory activity.

Keywords

Cordia dichotoma leaves extract, Acute inflammation, analgesic, Anti-inflammatory activity of Cordia dichotoma, Carrageenan-induced edema