Research article

HISTOMORPHOLOGICAL EVALUATION OF DATE PALM SEED (PHOENIX DACTYLIFERA L.) ON MAMMARY GLAND OF VIRGIN FEMALE RATS

Muayad N.K. 1*, Khalid K.K. 2

Online First: January 30, 2023


The present study was designed to evaluate the effect of ethanolic AL-Zahdy date seed extract (ZSE) on the growth and development of the mammary gland (MG) in female rats during virgin period. 20 healthy virgin female rats weighted (160-180) g were used, they divided into four groups (5/ each) according to ZSE daily oral dose including: Control group was administrated tap water, 200mg group was administrated of 200 mg/kg B.W., ZSE, 400 mg group were administrated of 400 mg/kg B.W., ZSE and 800 mg group were administrated of 800 mg/kg B.W., ZSE. For histological examination two stains were used Hematoxylin and Eosin and Massonʼs Trichrom and also some histometric measurements were utilized. Histological results showed the positive effect of ZSE on the development of ductal system in ZSE groups, the ductal width and length increased on account of adipose tissue with increasing the ZSE doses especially in 800 mg, with newly formed lobules and decreasing in cellular proliferation in terminal end bud of elongated ducts. Collagen bundles increased around the ductal system especially the elongated ducts. Histometrical results showed that the diameter, number of ducts and number of ductal epithelium increased significantly with the increasing the ZSE dose especially in 800mg subgroup in compared to others. In conclusion, the ZSE had positive effects on mammary gland at doses 400 and 800mg/ kg B.W., in virgin period.

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