ROLE OF CD 1B IN TUBERCULOSIS PATIENTS IN WASIT PROVINCE, IRAQ

Background and aims: Human leukocyte antigens (HLA), which are highly polymorphic (more than 26,000 alleles), present a variety of Mtb peptides to T-cells, which is considered a key element in the immune response against Mtb. On the other hand, lipids, glycolipids, and lipopeptides are presented to T cells by the non-polymorphic CD1 molecules. Several Mtb lipid antigens are presented by CD1 molecules such as CD1a, CD1b, CD1c, and CD1d, increasing the breadth of the T-cell responses to Mtb. Aim of study: The role of CD1b in the recognition and phagocytosis of Mycobacterium tuberculosis. Materials and methods: The current study has been conducted as a comparative case-control study in Wasit Province. The study consisted of 120 blood specimens collected from human individuals and divided into three groups, each consisting of 40 participants. Result: contains information about the diagnostic performance of different variables for treated and new untreated cases of tuberculosis (TB) groups. the CD1b appear diagnostic value in distinguishing between treated and (new) untreated cases of TB. The AUC values in the table indicate the ability of cd1b to discriminate between treated and new untreated TB cases. Higher AUC values (closer to 1) indicate better discriminatory power. 95% CI: a P-value less than a certain threshold (often 0. 05) suggest that the AUC is significantly different from a random classifier. Conclusion: The study showed that CD1B increased in newly diagnosed patients and decreased after two months of intensive treatment, while its percentage was normal in healthy people.